Laboratoire PPABIONUT



Publications Internationales






BADID N, BABA AHMED FZ, MERZOUK H, BELBRAOUET S, MOKHTARI N, MERZOUK SA, BENHABIB R, HAMZAOUI D, NARCE M (2010) Relationships between oxidant/antioxidant status, lipids, fatty acid composition and leptin in overweight women with breast cancer.

Pathology Oncology Research 16: 159-167; Editors: Kopper; Tímár; ISSN: 1219-4956; SPRINGER 


BOUDILMI-MALTI N, MERZOUK H, BABA AHMED FZ, MERZOUK SA, MALTI A, TESSIER C, NARCE M (2010) Oxidative stress biomarkers in obese mothers and their appropriate for gestational age newborns.

J Clin Diagnosis Res. 4: 2237-2245; Editor: Hemant Jain;  ISSN - 0973-709X ; PUBMED


BABA AHMED FZ, MERZOUK H, BOUANANE S, BENKALFAT NB, MERZOUK SA, KAJIMA MULENGI J, NARCE M (2010) Evaluation de la toxicité aigue de la 2- hydroxy-methyl-1 (N-phtaloyltryptophyl) aziridine chez le rat Wistar

Ann. Toxicologie. 22(3): 115-121; Editor:  Deveaux; ISSN: 0768-598X; PUBMED


BOUANANE S, MERZOUK H, BENKALFAT NB, SOULIMANE N, MERZOUK SA, GRESTI J, TESSIER C, NARCE M (2010) Hepatic and very low density lipoprotein fatty acids in obese offspring of overfed dams.

Metabolism Clinical and Experimental. 59 : 1701–1709; Editor Mantzoros; ISSN: 0026-0495 ; ELSEVIER


ARIBI M, MERZOUK H, HADDOUCHE M, BENYOUCEF M, TALEB A, KENDOUCI TANI M, MERZOUK SA, MEZIANE A (2010) Clinical evaluation of lipids, lipoproteins and red blood cells sodium and potassium in patients with different grades of hypertension.

Clinical Biochemistry. 43: 942-947 ; Editor : Kavsak ; ISSN : 0009-9120 ; ELSEVIER


SARI HASSOUNE M, MOKHTARI N, MERZOUK H, SAKER M, ABDELKADER ABID D (2010) Etude de quelques parameters lipidiques et du statut oxidant/antioxidant chez les enfants obèses de l’ouest algérien.

Obésité. 5 : 159 ; Editor Ziegler ; ISSN : 1951-6002 ; SPRINGER


KARAOUZENE N, MERZOUK H, ARIBI M, MERZOUK SA, YAHIA BERROUIGUET A, TESSIER C, NARCE M. (2011) Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men.

J nutrition metabolism cardiovascular diseases. 21 : 792-799; Editor: Strazzullo; ISSN: 0939-4753; ELSEVIER


MEDJDOUB A, MERZOUK SA, MERZOUK H, CHIALI FZ, NARCE M (2011) Effects of Mancozeb and Metribuzin on in vitro proliferative responses and oxidative stress of human and rat spleen lymphocytes stimulated by mitogens.

Pesticide Biochemistry and Physiology. 101: 27-33; Editor: Clark; ISSN: 0048-3575 ; ELSEVIER


SAKER M, MERZOUK H, MERZOUK SA, BABA AHMED S, NARCE M (2011). Predictive Factors of Obesity and their Relationships to Dietary Intake in Schoolchildren in Western Algeria.

Maedica. A Journal of Clinical Medicine. 6: 90-99; Editor: CINTEZA ; ISSN 1841-9038 ; PUBMED


BENKALFAT B , MERZOUK H, BOUANANE S, MERZOUK SA, BELLENGER J, GRESTI J, TESSIER CH, NARCE M. (2011) Altered adipose tissue metabolism in offspring of dietary obese dams.

Clinical Sciences, 121: 19-28; Editor Clinton Webb ; ISSN: 0143-5221; SPRINGER


MEZIANE RK, MERZOUK H, SAKER M, BABA AHMED S, NARCE M (2011) Fatty acids modulate in vitro T cell function in obese children. Annals of Biological Research, 2:170-177 ; Editor: Tongwen Xu; ISSN : 0976-1233 ; SCHOLARS


BABA HAMED Y, A. MEDJDOUB, B. MOSTEFA KARA, H. MERZOUK, D. VILLEMIN, M. NARCE (2012). 5,6-Dihydro-2H-pyranones and 5,6-dihydro-2H-pyridones and their derivatives modulate in vitro human T lymphocyte function.

Molecular and Cellular Biochemistry. 360 : 23-33; Editor: Dhalla; ISSN: 0300-8177 ; SPRINGER


BABA HAMED Y, A. MEDJDOUB, H. MERZOUK, M. NARCE (2012).Changes of in vitro Cytokine Production induced by δ-Lactams.

International Journal of Chemical and Biological Engineering. 6: 369-373; Editor:  Tolouei-Rad; ISSN: 2010-3875 ; PUBMED


SARI HASSOUN M, N. MOKHTARI SOULIMANE, H. MERZOUK (2012). Determination of lipid composition of organs and lipase activity in the offspring of rats fed cafeteria diet.
Clinical nutrition. 7 : 218-219. Editor: Deutz ; ISSN:  0261-5614 ; ELSEVIER


Ayad A, Merzouk H, Baba Hamed Y, Merzouk SA, Gresti J, Narce M (2013) Beneficial effects of dietary olive and linseed oils on serum and tissue lipids and redox status in the aging obese rat.

J. Nat. Prod. Plant Resour; 3(2):61-71; Editor: Ebenso; ISSN: 2231 – 3184 ; SCHOLARS


SARI HASSOUNE M, MOKHTARI N, MERZOUK H (2013) Obésité maternelle et désordres

métaboliques chez la progéniture.

Annales Biologie Clinique ; 71 : 45-46 ; Editor : Beaudeux ; ISSN : 0003-3898 ; ELSEVIER


CHIALI FZ, MERZOUK H, MERZOUK SA, MEDJDOUB A, NARCE M (2013). Chronic low level Metribuzin exposure induces metabolic alterations in rats.

Pesticide Biochemistry and Physiology. 106: 38-44.


LAISSOUF A, MOKHTARI-SOULIMANE N, MERZOUK H, BENHABIB N (2013). Dietary flaxseed oil supplementation improves the Oxidant/antioxidant status in obese aged rats.

International Journal of Medicine and Pharmaceutical Sciences (IJMPS). 3: 87-94.


AYAD A, MERZOUK H, MERZOUK S, NARCE M (2013). Blood oxidant / antioxidant status in overfed aging rats: comparative effects of sunflower, olive and linseed oil rich diets.

Biomedical and Environmental Sciences. 26: 390-393. ISSN: 0895-3988


KHEIRAT F, MERZOUK H, BOUDILMI N, MERZOUK SA, MALTI A, NARCE M (2013). Oxidative stress biomarkers in diabetic mothers and their newborns.

Annals of Biological Research. 4 (7):73-80. ISSN: 0976-1233


MALTI N, MERZOUK H, MERZOUK SA, LOUKIDI B, KARAOUZENE N, MALTI A, NARCE M (2014). Oxidative stress and maternal obesity: Feto-placental unit interaction.

Placenta. 1-6.


ALSAYADI M, AL JAWFI Y, BELARBI M, SOUALEM-MAMI Z, MERZOUK H, CHABAN SARI D, SABRI F, GHALIM M (2014). Evaluation of Anti-Hyperglycemic and Anti-Hyperlipidemic Activities of Water Kefir as Probiotic on Streptozotocin-Induced Diabetic Wistar Rats.

J Diabetes Mellitus. 4: 85-95.


GUERMOUCHE B, SOULIMANE-MOKHTARI NA, BOUANANE S, MERZOUK H, MERZOUK SA, NARCE M (2014). Effect of Dietary n - 3 Polyunsaturated Fatty Acids on Oxidant/Antioxidant Status in Macrosomic Offspring of Diabetic Rats.

BioMed Research International. ID 368107 : 1-9.


BABA HAMED Y, ATTAR T, HAREK Y, MERZOUK H, LARABI L (2014). Electrochemical and Biological Studies of Complex of Nickel (II) with a 2,5-Bis(2-pyridyl)-1,3,4-thiadiazole.

J. Chem. Bio. Phy. Sci. Sec. 4 : 1952-1959.


MEZIANE RK, MERZOUK H, SAKER M, BABAHMED S, NARCE M (2014). Effets des acides gras sur la prolifération lymphocytaire, la production d’interleukines et le statut oxydant dans un groupe d’enfants algériens

Lebanese science journal, volume 15 n°1.


BABA HAMED Y, MERZOUK H, HAREK Y, MEDJDOUB A, CHERRAK S, LARABI L, NARCE M (2014). In vitro effects of nickel (II) and copper (II) complexes with 2,5-bis(2-

pyridyl)-1,3,4-thiadiazole on T lymphocyte proliferation and intracellular redox status. Medicinal Chemistry Research. Med Chem Res. DOI 10.1007/s00044-014-1115-9


TABET-HELAL BOUALI SZ, CURMI PA, MERZOUK H (2014). Effects of stathmin n-terminal domain mutations on cell cycle, microtubules assembly and dynamics in hela cells.

International Journal of Medicine and Pharmaceutical Sciences. 4 : 91-106.


SAKER M, MERZOUK H (2014). Stress environnemental oxydatif et immunité chez l’enfant obèse. Livre édition PAF 238 pages.


BABA HAMED Y, MERZOUK H, HAREK Y, MEDJDOUB A, CHERRAK S, LARABI L, NARCE M (2015). In vitro effects of nickel (II) and copper (II) complexes with 2,5-bis(2-

pyridyl)-1,3,4-thiadiazole on T lymphocyte proliferation and intracellular redox status. Medicinal Chemistry Research. 24: 764-772.


EL HASSAR CH, MERZOUK H, MERZOUK SA, MALTI N, MEZIANE A, NARCE M (2015). Long term use of angiotensin II receptor antagonists and calcium-channel antagonists in Algerian hypertensive patients: effects on metabolic and oxidative parameters. Free radical biology & medicine. 79: 147-153.


BOUDGHENE STAMBOULI GUERRICHE A, MOKHTARI SOULIMANE N, MERZOUK H, MERZOUK SA, BENDEDOUCHE AS (2015). Elevation of oxidative stress markers in Type 1 diabetic children. J Diabetes Endocrinology. 6:5-11.


BOUCHRA LOUKIDI, HAFIDA MERZOUK, SID AHMED MERZOUK, NASSIMA MALTI, KATIA TAOULI, BOUMEDIENE BELARBI & MICHEL NARCE (2015). Thrombosis factors and oxidant / antioxidant markers in obese and hypertensive women during pregnancy. Blood Pressure; Early Online : 1–8.


BENAISSA N, MERZOUK H, MERZOUK SA, NARCE M (2015). Effects of maternal linseed oil supplementation on metabolic parameters in cafeteria diet induced obese rats. Biomedical and Environmental Sciences. In press


MERIEM RABIA ZAHZEH, BOUCHRA LOUKIDI, WARDA MEZIANE, MUSTAPHA HADDOUCHE, NAIMA MESLI, ZAHIA ZOUAOUI, MOURAD ARIBI (2015). Relationship between NADPH and th1/th2 ratio in patients with non-Hodgkin lymphoma who have been exposed to pesticides. Journal of blood medicine. 31 - 6.


Farah DJELTI, Hafida MERZOUK, Sid Ahmed MERZOUK and Michel NARCE (2015). In vitro effects of oil’s fatty acids on t cell function in gestational diabetic pregnant women and their newborns. Journal of Diabetes. 7 : 512–522. ISSN : 1753-0407


Fatima Zohra Madani, Merzouk Hafida, Sid Ahmed Merzouk, Bouchra

Loukidi, Katia Taouli & Michel Narce (2015). Hemostatic, inflammatory, and oxidative markers in pesticide user farmers. Biomarkers, Early Online: 1–8.


Selma Bereksi Reguig, Samira Bouanane, Hafida Merzouk, Nabila Soufi4, Sid Ahmed Merzouk3 (2015). Oxidative Stress and Thrombotic Disorders: Study in Patients with Venous Thromboembolism. International Journal of Health Sciences & Research. Vol 6.1: 185-194


Amina Boudghene Stambouli, Nassima Mokhtari Soulimane, Hafida Merzouk, Sid Ahmèd Merzouk and Ahmed Salih Bendedouche (2015). Elevation of oxidative stress markers in type 1 diabetic children. Journal of diabetes and Endocrinology. Vol 6 (2), pp 5-11.


DJAMILA ABDELKADER ABID, NASSIMA MOKHTARI-SOULIMANE*, HAFIDA MERZOUK, MICHEL NARCE (2016). Linseed oil supplementation improves lecithin cholesterol acyltransferase and tissue lipase activities in pregnant obese rats and their offspring. International Journal of Pharmacy and Pharmaceutical Sciences. 8 :194-200.


Bensalah Meryem, Bouanane Samira, Baba Ahmed Fatima Zohra, Merzouk Hafida, Sid Ahmed Merzouk and Narce Michel (2016). Effect of cafeteria diet on lipid metabolism and lipase activities in wistar rats. Eur. Chem. Bull. 5(3) : 99-103


Asmahan Imessaoudene, Hafida Merzouk, Farid Berroukeche, Nassima Mokhtari, Bachir Bensenane, Sabri Cherrak, Sid Ahmed Merzouk, Mourad Elhabiri (2016) . Beneficial effects of quercetin–iron complexes on serum and tissue lipids and redox

status in obese rats. Journal of Nutritional Biochemistr . 29: 107–115.


Fadia Bekhti-Sari, Nassima Mokhtari-Soulimane, Hafida Merzouk, Lotfi Loudjedi, Sabah Ghedouchi, Baya Guermouche, Sid Ahmed Merzouk, Necib Berber (2016). International Journal of Health Sciences & Research. Vol.6. 3 : 118-126


Kheirat Farah, Merzouk Hafida, Merzouk Sid Ahmed, Loukidi Bouchra, Saker Meriem, Belarbi Boumediene (2016). Inflammatory and Redox Markers in Overweight and Obese Menopausal Women. International Journal of Health Sciences & Research. Vol.6. 4 : 174-184


Djamila Mezouar, Hafida Merzouk, Amel Saidi Merzouk, Sid Ahmed Merzouk,

Boumediene Belarbi, Michel Narce (2016). In vitro effects of vitamins C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell function and redox status in type 1 diabetic pregnant women. Placenta. 42 : 114e121.


Sabah Gheddouchi, Nassima Mokhtari-Soulimane, Hafida Merzouk, Fadia Bekhti,

Fayçal Soulimane, Baya Guermouche, Abderrahim Meziane Tani, Michel Narce (2016). Low SOD activity is associated with overproduction of peroxynitrite

and nitric oxide in patients with acute coronary syndrome. Nitric Oxide. 49 :40-46.


Saidi A., Baba-Ahmed F. Z., Merzouk H., Bouanane S., Derouiche S. and Merzouk S. A. (2016). Effect of Linseed Oil on Oxidative Stress Parameters and Lipid Profile in Offspring of Obese Rats. J Phys Pharm Adv. 6(4): 860-867.


Salima Derouiche, Fatima Zohra Baba Ahmed, Hafida Merzouk, Samira

Bouanane, Abdettouweb Saidi, Sid Ahmed Merzouk and Narce Michel (2016). The long term effect of maternal olive oil supplementation on metabolic and redox status in offspring of obese rats. Eur. Chem. Bull. 5(1) : 8-13.


Berroukeche Farid, Mokhtari-Soulimane Nassima, Imessaoudene Asmahan, Cherrak Ahmed Sabri, Merzouk Hafida and Elhabiri Mourad (2016). Iron-quercetin complex reduces lipid and protein oxidation in streptozotocin diabetic rats complications independently to glucose lowering. World Journal of Pharmaceutical Research. Vol 5. 3: 1690-1723.


F.Z. Baba Ahmeda, S. Bouanane, H. Merzouk, N. Soufi (2016). Effet des acides gras polyinsaturés N-3 sur la modulation in vitro deslymphocytes T et le statut redox chez les femmes obèses hypertendues. Annales de Cardiologie et d’Angéiologie. 1-5.


Leila Hocine, Hafida Merzouk, Sid Ahmed Merzouk, Hafeda Ghorzi, Meriem Youbi, Michel Narce (2016). The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns. Pesticide Biochemistry and Physiology. 1-6.




Publications Nationales



MERZOUK H (2012) L’équilibre acide base. Bulletin Orth. 3 : 58-61. ISSN : 2170-1539 ; www.orthomoleculaire.org


MERZOUK H (2012) Le Glutathion. Bulletin Orth. 3 : 62-69. ISSN : 2170-1539 ; www.orthomoleculaire.org


GHORZI H (2012) la supplementation du régime hyperlidique (cafeteria) en l’huile de lin réduit la prise de poids et améliore la glycémie et le profil lipidique chez les rats femelles wistar. Bulletin Orth. 3 : 92-98. ISSN : 2170-1539 ; www.orthomoleculaire.org


HOCINE L (2012) Altérations métaboliques chez la progéniture de rates obeses nourries au régime cafeteria. Bulletin Orth. 3 : 99-103. ISSN : 2170-1539 ; www.orthomoleculaire.org


MERZOUK H, MALTI N, LOUKIDI B, MALTI A (2012) la macrosomie foetale : syndrome plurim2tabolique et effets protecteurs des AGPI n-3. Bulletin Orth. 3 : 109-114. <sp